ChemicalBook > CAS DataBase List > 8-M-PDOT
8-M-PDOT
- Product Name
- 8-M-PDOT
- CAS No.
- 134865-70-6
- Chemical Name
- 8-M-PDOT
- Synonyms
- AH 002;8-M-PDOT;8 M PDOT,8MPDOT;8-METHOXY-2-PROPIONAMIDOTETRALIN;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
- CBNumber
- CB9487996
- Molecular Formula
- C14H19NO2
- Formula Weight
- 233.31
- MOL File
- 134865-70-6.mol
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8-M-PDOT Property
- Boiling point:
- 447.8±45.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 50 mM in ethanol and to 100 mM in DMSO
- form
- Powder
- pka
- 15.87±0.20(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 29521
- Product name
- 8-M-PDOT
- Packaging
- 5mg
- Price
- $82
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29521
- Product name
- 8-M-PDOT
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29521
- Product name
- 8-M-PDOT
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29521
- Product name
- 8-M-PDOT
- Packaging
- 50mg
- Price
- $606
- Updated
- 2024/03/01
Tocris
- Product number
- 1035
- Product name
- 8-M-PDOT
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $504
- Updated
- 2021/12/16
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8-M-PDOT Chemical Properties,Usage,Production
Description
8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.
Uses
AH 002 is a selective melatonin receptor agonist.
Biological Activity
Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.
8-M-PDOT Preparation Products And Raw materials
Raw materials
Preparation Products
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